Cell-cell junction maintenance

Across TCGA cell cohorts, RNA activity of the Cell-cell junction maintenance pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX8, ZFP14, and RBM20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOX8 grouped by Cell-cell junction maintenance-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SOX8 →	+2.747	+0.942	<.001	.002	3	4
BONE	ZFP14 →	+0.948	+0.353	.006	.004	3	3
CNS	RBM20 →	+1.003	+0.696	<.001	<.001	3	3
PANCREAS	NBPF12 →	+0.567	+0.989	.004	.002	3	3
CNS	RCOR2 →	+1.188	+0.824	<.001	<.001	3	3
OVARY	ALKBH6 →	+0.724	+0.781	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOX8 by Cell-cell junction maintenance activity — SKIN

Explore this box plot interactively →