Sarcomere organization

Across TCGA patient cohorts, RNA activity of the Sarcomere organization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNC, FLNA_S968, and FN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sarcomere organization activity versus TNC in PDAC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TNC →	+0.919	+0.041	<.001	.002	3	6
UCEC	FLNA_S968 →	+0.797	+0.066	.008	.001	3	6
LSCC	FN1 →	+0.619	+0.046	<.001	.006	3	6
LUAD	LOXL2 →	+0.757	+0.059	<.001	<.001	3	6
GBM	MYH9 →	+0.476	+0.061	<.001	.001	3	6
LSCC	CCN1 →	+0.736	+0.081	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045214 vs TNC — PDAC

Explore this scatter interactively →