Sarcomere organization

Across TCGA cell cohorts, RNA activity of the Sarcomere organization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYCR3, SLC25A2, and CLEC7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PYCR3 grouped by Sarcomere organization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PYCR3 →	+0.489	+0.955	.009	.002	2	5
KIDNEY	SLC25A2 →	-0.053	-1.347	.006	.003	3	4
UPPER_AERODIGESTIVE_TRACT	CLEC7A →	-1.322	-1.019	.009	.009	3	4
BLOOD_Myeloma	TRAF6 →	-0.871	-0.862	.003	.009	3	4
BLOOD_Myeloma	ZBED5 →	-0.899	-1.407	.003	<.001	3	4
BLOOD_Myeloma	PLEKHH3 →	-1.066	-0.972	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PYCR3 by Sarcomere organization activity — CNS

Explore this box plot interactively →