Sarcomere organization

Across TCGA cell cohorts, RNA activity of the Sarcomere organization pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX9, NCKAP1, and PROCR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHX9 grouped by Sarcomere organization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DHX9 →	-0.271	-0.182	.002	.003	3	5
BREAST	NCKAP1 →	+0.148	+0.128	.009	.004	3	4
LARGE_INTESTINE	PROCR →	-0.182	-0.186	.005	<.001	3	4
BONE	ALDOC →	-0.313	-0.259	.003	.003	3	4
PANCREAS	EFCAB6 →	-0.251	-0.167	.003	.004	3	4
PANCREAS	SRSF10 →	+0.236	+0.108	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHX9 by Sarcomere organization activity — CNS

Explore this box plot interactively →