Sarcomere organization

Across TCGA cell cohorts, RNA activity of the Sarcomere organization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICAL2, CD151, and TPM1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sarcomere organization activity versus MICAL2 in LIVER (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MICAL2 →	+2.985	+0.215	.001	.009	3	14
BONE	CD151 →	+1.992	+0.304	<.001	<.001	3	13
BONE	TPM1 →	+3.517	+0.241	<.001	<.001	3	13
BONE	PLEC →	+2.171	+0.312	<.001	<.001	3	13
LUNG_SCLC	KRT8 →	+3.712	+0.260	<.001	<.001	3	12
BONE	SDC4 →	+2.153	+0.227	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045214 vs MICAL2 — LIVER

Explore this scatter interactively →