Sarcomere organization

Across TCGA cell cohorts, RNA activity of the Sarcomere organization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTN4, ANXA3, and FLNA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sarcomere organization activity versus ACTN4 in SOFT_TISSUE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACTN4 →	+1.420	+0.324	.006	.007	3	7
OESOPHAGUS	ANXA3 →	+2.687	+0.216	<.001	.009	3	7
BLOOD_Lymphoma	FLNA →	+2.014	+0.213	.001	.004	3	7
SKIN	S100A10 →	+1.088	+0.354	.003	.002	3	6
OESOPHAGUS	TES →	+1.832	+0.365	.009	.002	3	6
STOMACH	SH3RF1 →	+1.264	+0.300	.008	.009	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045214 vs ACTN4 — SOFT_TISSUE

Explore this scatter interactively →