Establishment of epithelial cell apical/basal polarity

Across TCGA patient cohorts, RNA activity of the Establishment of epithelial cell apical/basal polarity pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTPS2, CYBA, and CYBB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of epithelial cell apical/basal polarity activity versus CTPS2 in COAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CTPS2 →	+0.320	+0.029	<.001	<.001	3	7
PDAC	CYBA →	-0.476	-0.033	.002	.002	3	7
PDAC	CYBB →	-0.629	-0.036	<.001	.002	3	7
UCEC	TAPBP →	-0.521	-0.049	.004	.003	2	7
HNSC	TRAPPC9_S953 →	-0.284	-0.067	.002	.003	2	7
LSCC	CCL5 →	-0.526	-0.045	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045198 vs CTPS2 — COAD

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