Establishment of epithelial cell apical/basal polarity

Across TCGA patient cohorts, RNA activity of the Establishment of epithelial cell apical/basal polarity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFA9, HILPDA, and DCLRE1C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of epithelial cell apical/basal polarity activity versus NDUFA9 in HNSC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NDUFA9 →	-0.314	-0.531	<.001	.005	3	4
UCEC	HILPDA →	+1.105	+0.798	<.001	<.001	3	3
HNSC	DCLRE1C →	-0.385	-0.779	.001	.003	3	3
HNSC	CSTB →	+1.049	+0.676	<.001	<.001	3	3
HNSC	DMKN →	+1.244	+0.724	<.001	.001	3	3
HNSC	POGLUT1 →	-0.347	-1.008	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045198 vs NDUFA9 — HNSC

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