Regulation of isotype switching

Across TCGA cell cohorts, RNA activity of the Regulation of isotype switching pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXR, LEPROTL1, and PIK3R2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FDXR grouped by Regulation of isotype switching-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FDXR →	-1.370	-0.293	.002	.002	3	5
CNS	LEPROTL1 →	-0.817	-0.526	<.001	.001	3	4
CNS	PIK3R2 →	-0.692	-0.447	.006	.005	3	4
OESOPHAGUS	CAPN2 →	+1.107	+0.239	.001	.003	3	4
BLOOD_Leukemia	FAM114A2 →	-0.841	-0.265	<.001	.003	3	4
SKIN	ZNF34 →	-0.422	-0.212	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FDXR by Regulation of isotype switching activity — LUNG_SCLC

Explore this box plot interactively →