Regulation of isotype switching

Across TCGA cell cohorts, RNA activity of the Regulation of isotype switching pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSH2, ZBTB10, and FBXL19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of isotype switching activity versus MSH2 in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MSH2 →	+0.845	+0.219	.003	.008	3	6
OVARY	ZBTB10 →	+1.179	+0.235	.009	.003	3	6
OVARY	FBXL19 →	+0.714	+0.309	.005	<.001	3	5
OVARY	EHMT2 →	+0.890	+0.214	.004	.005	3	4
CNS	PTK7 →	+1.564	+0.245	.002	<.001	3	4
CNS	VASH1 →	+1.313	+0.249	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045191 vs MSH2 — PANCREAS

Explore this scatter interactively →