Maintenance of protein location

Across TCGA patient cohorts, RNA activity of the Maintenance of protein location pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPN, ACTA2, and AKT3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein location activity versus ASPN in OV (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ASPN →	+1.629	+0.133	<.001	<.001	3	6
BRCA	ACTA2 →	+1.355	+0.194	<.001	<.001	3	6
OV	AKT3 →	+1.010	+0.152	<.001	<.001	3	6
UCEC	GLT8D2 →	+1.909	+0.377	.007	.009	3	6
OV	CALD1 →	+1.305	+0.171	<.001	<.001	3	6
OV	PDGFRA →	+0.976	+0.120	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045185 vs ASPN — OV

Explore this scatter interactively →