Maintenance of protein location

Across TCGA cell cohorts, RNA activity of the Maintenance of protein location pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN1, GNAO1, and ACLY, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN1 grouped by Maintenance of protein location-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TLN1 →	+0.508	+0.126	.001	.001	3	6
BREAST	GNAO1 →	+0.232	+0.064	<.001	.008	3	5
BREAST	ACLY →	-0.408	-0.096	.001	<.001	3	5
OVARY	SLC7A11 →	+0.139	+0.074	.008	<.001	3	5
BLOOD_Leukemia	EDIL3 →	-0.277	-0.077	.009	<.001	3	5
LIVER	TEAD1 →	+0.582	+0.126	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN1 by Maintenance of protein location activity — LIVER

Explore this box plot interactively →