Maintenance of protein location

Across TCGA cell cohorts, RNA activity of the Maintenance of protein location pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOSTRIN, SUOX, and NMT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein location activity versus NOSTRIN in BONE (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NOSTRIN →	-0.964	-0.223	.002	<.001	3	6
PANCREAS	SUOX →	-0.885	-0.162	.004	.005	3	6
OVARY	NMT2 →	+1.123	+0.215	.001	<.001	3	6
BREAST	VPS45 →	-0.855	-0.225	.002	.005	3	6
OESOPHAGUS	SPHK2 →	-0.704	-0.232	.005	<.001	3	5
OVARY	NALCN →	+1.790	+0.225	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045185 vs NOSTRIN — BONE

Explore this scatter interactively →