Apical protein localization

Across TCGA patient cohorts, RNA activity of the Apical protein localization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDS1, SHROOM3, and SHROOM3-AS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apical protein localization activity versus CDS1 in UCEC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDS1 →	+0.856	+0.682	<.001	<.001	3	7
BRCA	SHROOM3 →	+1.302	+0.785	<.001	<.001	3	6
PDAC	SHROOM3-AS1 →	+0.878	+0.846	<.001	<.001	3	6
BRCA	SHROOM2 →	+0.870	+0.518	<.001	.001	3	6
UCEC	TSPAN1 →	+1.784	+0.672	<.001	<.001	3	6
BRCA	PEX11A →	+1.017	+0.461	<.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045176 vs CDS1 — UCEC

Explore this scatter interactively →