Apical protein localization

Across TCGA cell cohorts, RNA activity of the Apical protein localization pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTFP1, BRD2, and ETFA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apical protein localization activity versus MTFP1 in KIDNEY (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MTFP1 →	-1.093	-1.815	.001	<.001	3	3
CNS	BRD2 →	+0.500	+0.773	<.001	.009	3	3
OESOPHAGUS	ETFA →	-0.691	-0.993	.003	.002	3	3
OESOPHAGUS	COX5A →	-0.665	-1.242	.007	.001	3	3
BONE	B4GALNT2 →	+0.420	+1.775	.004	<.001	3	3
STOMACH	CCDC192 →	+0.370	+1.789	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045176 vs MTFP1 — KIDNEY

Explore this scatter interactively →