Cell fate commitment

Across TCGA cell cohorts, RNA activity of the Cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR5, TAF10, and FUCA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRR5 grouped by Cell fate commitment-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRR5 →	+0.627	+0.179	.002	.005	3	5
LUNG_NSCLC_LUSC	TAF10 →	-0.908	-0.248	<.001	.002	3	4
KIDNEY	FUCA1 →	-1.662	-0.238	<.001	.005	2	5
LUNG_NSCLC_LUSC	TGOLN2 →	-1.356	-0.369	.001	<.001	3	4
LUNG_NSCLC_LUSC	CUEDC1 →	-1.791	-0.270	.008	.004	3	4
LUNG_NSCLC_LUSC	ITGB5 →	-1.854	-0.353	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRR5 by Cell fate commitment activity — PANCREAS

Explore this box plot interactively →