Cell fate commitment

Across TCGA cell cohorts, RNA activity of the Cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE2A, BBOF1, and ARL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell fate commitment activity versus PDE2A in LIVER (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PDE2A →	+0.900	+0.240	.005	.004	3	4
BLOOD_Myeloma	BBOF1 →	+1.074	+0.223	.003	<.001	3	3
BLOOD_Leukemia	ARL3 →	+0.568	+0.132	.002	<.001	3	3
BLOOD_Myeloma	NLRX1 →	+1.595	+0.235	.004	<.001	3	3
BLOOD_Leukemia	MCRIP1 →	+0.977	+0.134	<.001	.004	3	3
BLOOD_Leukemia	RBM8A →	+0.481	+0.127	.003	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045165 vs PDE2A — LIVER

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