Neuronal ion channel clustering

Across TCGA patient cohorts, RNA activity of the Neuronal ion channel clustering pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NRCAM, SERPIND1, and SHMT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal ion channel clustering activity versus NRCAM in UCEC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NRCAM →	+0.829	+0.094	<.001	<.001	3	7
GBM	SERPIND1 →	-0.535	-0.074	.003	.003	3	6
LSCC	SHMT2 →	+0.379	+0.042	.002	.008	3	5
HNSC	CFL2 →	-0.565	-0.054	<.001	<.001	3	5
GBM	TLN1 →	-0.283	-0.071	<.001	<.001	3	5
BRCA	DCN →	-0.675	-0.042	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045161 vs NRCAM — UCEC

Explore this scatter interactively →