Neuronal ion channel clustering

Across TCGA cell cohorts, RNA activity of the Neuronal ion channel clustering pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF12A, MRPL34, and ZNF185, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal ion channel clustering activity versus TNFRSF12A in LARGE_INTESTINE (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNFRSF12A →	+1.670	+1.256	<.001	<.001	3	6
BREAST	MRPL34 →	-0.860	-1.128	.002	.004	3	5
LUNG_NSCLC_LUSC	ZNF185 →	+3.305	+1.867	.001	<.001	3	5
LARGE_INTESTINE	ANXA11 →	+0.844	+1.227	.003	.001	3	5
LARGE_INTESTINE	AHNAK →	+1.588	+1.449	<.001	<.001	3	5
LARGE_INTESTINE	MYOF →	+2.560	+1.466	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045161 vs TNFRSF12A — LARGE_INTESTINE

Explore this scatter interactively →