Homologous chromosome segregation

Across TCGA patient cohorts, RNA activity of the Homologous chromosome segregation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, RFC1_T506, and RRM2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homologous chromosome segregation activity versus RFC1_S368 in LUAD (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_S368 →	+0.910	+0.070	<.001	<.001	3	10
BRCA	RFC1_T506 →	+1.113	+0.047	<.001	<.001	3	10
LUAD	RRM2 →	+0.860	+0.073	<.001	<.001	3	10
OV	RRP36_S73 →	+0.874	+0.034	<.001	.009	3	10
LUAD	ATAD2_S342 →	+1.273	+0.060	<.001	<.001	3	10
BRCA	SMARCA5 →	+0.302	+0.044	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045143 vs RFC1_S368 — LUAD

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