Homologous chromosome segregation

Across TCGA cell cohorts, RNA activity of the Homologous chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHPT1, SAMD4B, and DAAM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homologous chromosome segregation activity versus PHPT1 in LUNG_NSCLC_LUAD (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PHPT1 →	-0.482	-0.542	<.001	.001	3	4
LIVER	SAMD4B →	+0.434	+1.010	.005	.005	3	4
SOFT_TISSUE	DAAM1 →	+1.203	+0.943	.003	.001	3	4
STOMACH	MRPS25 →	-0.583	-0.942	.002	.008	3	4
UPPER_AERODIGESTIVE_TRACT	CHCHD4 →	-1.221	-1.378	.002	<.001	3	4
BONE	ATP6AP1 →	+1.311	+1.194	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045143 vs PHPT1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →