Development of primary sexual characteristics

Across TCGA patient cohorts, RNA activity of the Development of primary sexual characteristics pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DENND1C, SEC23B, and TGFB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Development of primary sexual characteristics activity versus DENND1C in UCEC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DENND1C →	-0.521	-0.032	.009	.002	3	6
LSCC	SEC23B →	-0.204	-0.018	<.001	<.001	3	5
LUAD	TGFB2 →	+0.478	+0.015	<.001	.005	3	5
LUAD	CCDC88B_S1379 →	-0.376	-0.015	<.001	<.001	3	5
BRCA	CCN2 →	+0.561	+0.024	.003	<.001	3	5
LSCC	CELF1 →	+0.160	+0.014	.005	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045137 vs DENND1C — UCEC

Explore this scatter interactively →