Development of primary sexual characteristics

Across TCGA patient cohorts, RNA activity of the Development of primary sexual characteristics pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RETN, DNAJB9, and ALOX5AP, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Development of primary sexual characteristics activity versus RETN in COAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RETN →	+1.059	+0.786	<.001	<.001	3	2
COAD	DNAJB9 →	+0.459	+0.484	.001	.004	3	2
COAD	ALOX5AP →	+0.820	+0.825	.003	<.001	3	2
COAD	TSPAN2 →	+0.710	+0.693	.004	<.001	3	2
COAD	FGF2 →	+0.439	+0.412	.004	.007	3	2
COAD	SHC4 →	+0.233	+0.511	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045137 vs RETN — COAD

Explore this scatter interactively →