Development of primary sexual characteristics

Across TCGA cell cohorts, RNA activity of the Development of primary sexual characteristics pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUT4, CPLANE1, and KAT2B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Development of primary sexual characteristics activity versus TUT4 in BLOOD_Leukemia (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TUT4 →	-0.563	-0.046	.002	.003	3	8
LARGE_INTESTINE	CPLANE1 →	-0.934	-0.041	.001	.001	3	8
SKIN	KAT2B →	-1.272	-0.061	.006	.001	2	9
BLOOD_Lymphoma	SCO1 →	-0.650	-0.044	.001	<.001	3	8
URINARY_TRACT	DZIP3 →	-1.512	-0.084	.001	.005	3	8
BLOOD_Lymphoma	ELAC2 →	-0.727	-0.047	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045137 vs TUT4 — BLOOD_Leukemia

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