Development of primary sexual characteristics

Across TCGA cell cohorts, RNA activity of the Development of primary sexual characteristics pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A3, ARHGDIB, and SNAP47, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Development of primary sexual characteristics activity versus SLC1A3 in STOMACH (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC1A3 →	-4.132	-0.252	<.001	.003	3	5
BREAST	ARHGDIB →	-2.565	-0.218	.005	.002	3	5
SKIN	SNAP47 →	-0.405	-0.199	.006	.003	3	5
LARGE_INTESTINE	VAPB →	+0.583	+0.166	.009	<.001	3	4
URINARY_TRACT	GJB5 →	-3.877	-0.375	.006	.004	3	4
BLOOD_Lymphoma	ZDHHC14 →	-2.232	-0.188	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045137 vs SLC1A3 — STOMACH

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