Azole transmembrane transport

Across TCGA patient cohorts, RNA activity of the Azole transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC44A4, BAZ1B_S361, and MKI67_T1801, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Azole transmembrane transport activity versus SLC44A4 in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC44A4 →	+0.959	+0.082	<.001	<.001	3	4
UCEC	BAZ1B_S361 →	-0.752	-0.100	.001	.001	3	4
OV	MKI67_T1801 →	-0.970	-0.080	.002	.005	3	4
COAD	EI24_S330 →	-0.511	-0.057	.003	.004	3	4
COAD	PRPF39 →	-0.209	-0.042	.002	.007	3	4
GBM	GLCCI1_S148 →	-0.694	-0.048	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045117 vs SLC44A4 — CCRCC

Explore this scatter interactively →