Azole transmembrane transport

Across TCGA patient cohorts, RNA activity of the Azole transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXC5, ANKDD1B, and NDFIP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Azole transmembrane transport activity versus HOXC5 in HNSC (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HOXC5 →	-0.369	-0.486	.004	.002	3	3
HNSC	ANKDD1B →	-0.542	-0.491	.001	.001	3	3
CCRCC	NDFIP2 →	+0.289	+0.542	.009	.002	3	3
CCRCC	DCDC2 →	+1.023	+0.650	.001	.003	3	3
COAD	IGHD3-9 →	-1.302	-0.640	.001	.005	3	3
COAD	ANKRD36BP2 →	-0.545	-0.624	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045117 vs HOXC5 — HNSC

Explore this scatter interactively →