Azole transmembrane transport

Across TCGA cell cohorts, RNA activity of the Azole transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHJ1, PLAAT1, and MAP3K10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLEKHJ1 grouped by Azole transmembrane transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PLEKHJ1 →	-0.531	-0.821	.004	.005	3	5
URINARY_TRACT	PLAAT1 →	+2.196	+1.362	<.001	.004	3	4
OVARY	MAP3K10 →	-0.871	-0.836	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	TEFM →	-0.888	-1.098	.005	.007	3	4
UPPER_AERODIGESTIVE_TRACT	RABL6 →	-1.146	-1.369	.009	.005	3	4
SKIN	IPO4 →	-0.637	-0.906	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLEKHJ1 by Azole transmembrane transport activity — CNS

Explore this box plot interactively →