Azole transmembrane transport

Across TCGA cell cohorts, RNA activity of the Azole transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPR2, PTTG3P, and KCNH6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPR2 grouped by Azole transmembrane transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NPR2 →	+0.140	+1.924	.005	.001	2	3
LARGE_INTESTINE	PTTG3P →	+0.277	+0.495	.001	.005	3	2
PANCREAS	KCNH6 →	-0.165	-0.405	.004	.004	3	1
PANCREAS	XPOT →	-0.155	-0.405	.005	.004	3	1
PANCREAS	RAD54B →	-0.370	-0.405	.004	.004	3	1
PANCREAS	OGDHL →	+0.405	+0.405	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPR2 by Azole transmembrane transport activity — OVARY

Explore this box plot interactively →