Azole transmembrane transport

Across TCGA cell cohorts, RNA activity of the Azole transmembrane transport pathway is significantly associated with the drug response of multiple features, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are SB52334, BAY AKT1, and AZD3514, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SB52334 grouped by Azole transmembrane transport-low versus -high activity in SKIN.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SB52334 →	+1.032	+0.368	.021	.007	3	4
BLOOD_Leukemia	BAY AKT1 →	-2.030	-0.506	.020	.022	3	3
SKIN	AZD3514 →	+0.455	+0.368	.028	.007	3	3
PANCREAS	HG6-64-1 →	+0.559	+0.310	.035	.012	3	3
PANCREAS	JAK1_8709 →	+0.771	+0.274	.039	.042	2	4
BONE	Pilaralisib →	-0.950	-0.596	.017	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SB52334 by Azole transmembrane transport activity — SKIN

Explore this box plot interactively →