Regulation of integrin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of integrin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFB2, OSM, and POM121L9P, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of integrin biosynthetic process activity versus TGFB2 in LSCC (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TGFB2 →	+1.306	+0.148	<.001	<.001	3	6
HNSC	OSM →	+1.561	+0.059	<.001	.003	3	5
GBM	POM121L9P →	+0.746	+0.153	<.001	<.001	3	5
COAD	CLDN12 →	+0.529	+0.114	.001	.002	3	4
GBM	CD300E →	+0.849	+0.122	<.001	<.001	3	4
HNSC	FXYD6 →	-0.611	-0.073	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045113 vs TGFB2 — LSCC

Explore this scatter interactively →