Regulation of integrin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of integrin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF12, ZFYVE26, and NFAT5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF12 grouped by Regulation of integrin biosynthetic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KLF12 →	-1.502	-1.444	.003	<.001	3	4
BLOOD_Myeloma	ZFYVE26 →	+1.317	+1.443	.008	.009	3	4
BONE	NFAT5 →	+1.470	+2.266	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	TNKS2 →	+0.995	+0.908	<.001	.008	3	3
BONE	WASHC3 →	+0.635	+1.779	.003	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	OGA →	+0.964	+0.911	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF12 by Regulation of integrin biosynthetic process activity — URINARY_TRACT

Explore this box plot interactively →