Intermediate filament organization

Across TCGA patient cohorts, RNA activity of the Intermediate filament organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A2, TNRC6C, and KRT23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermediate filament organization activity versus S100A2 in LSCC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	S100A2 →	+1.571	+0.103	<.001	<.001	3	5
OV	TNRC6C →	-0.643	-0.062	.005	.002	3	5
PDAC	KRT23 →	+1.008	+0.084	<.001	<.001	3	5
BRCA	KRT23_S65 →	+1.470	+0.109	<.001	<.001	3	5
BRCA	PPP1R9A_S840 →	-0.710	-0.057	<.001	<.001	3	5
LSCC	PLEC_S1284 →	+0.915	+0.115	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045109 vs S100A2 — LSCC

Explore this scatter interactively →