Intermediate filament organization

Across TCGA cell cohorts, RNA activity of the Intermediate filament organization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT16, KRT18, and PDXP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermediate filament organization activity versus KRT16 in OVARY (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRT16 →	+2.021	+0.409	.003	.003	3	8
SOFT_TISSUE	KRT18 →	+5.074	+0.254	.009	.001	1	9
URINARY_TRACT	PDXP →	-1.621	-0.516	.008	<.001	3	7
BREAST	KRT8 →	+3.019	+0.392	.001	.009	3	7
URINARY_TRACT	DAPP1 →	+3.367	+0.494	<.001	<.001	3	7
PANCREAS	UPK3B →	+3.752	+0.321	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045109 vs KRT16 — OVARY

Explore this scatter interactively →