Intermediate filament-based process

Across TCGA patient cohorts, RNA activity of the Intermediate filament-based process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KRT23_S65, KRT5_S77, and GPX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermediate filament-based process activity versus KRT23_S65 in COAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KRT23_S65 →	+1.523	+0.037	.001	<.001	3	5
PDAC	KRT5_S77 →	+3.229	+0.063	<.001	.006	3	5
LSCC	GPX2 →	+0.936	+0.046	<.001	<.001	3	5
COAD	HSD17B10 →	+0.323	+0.026	.004	.003	3	4
PDAC	KRT23 →	+0.958	+0.049	<.001	<.001	3	4
COAD	PDP1 →	+0.322	+0.028	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045103 vs KRT23_S65 — COAD

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