Intermediate filament-based process

Across TCGA patient cohorts, RNA activity of the Intermediate filament-based process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RX3, MBIP, and C5, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermediate filament-based process activity versus P2RX3 in CCRCC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	P2RX3 →	+0.152	+0.992	.007	.008	3	2
CCRCC	MBIP →	+0.458	+1.286	.007	<.001	3	2
BRCA	C5 →	-1.104	-0.582	.001	.005	3	2
BRCA	CST9 →	-1.729	-0.621	.006	.005	3	2
BRCA	RMI1 →	-0.819	-0.628	<.001	.004	3	2
BRCA	NCCRP1 →	+2.155	+0.561	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045103 vs P2RX3 — CCRCC

Explore this scatter interactively →