Intermediate filament-based process

Across TCGA cell cohorts, RNA activity of the Intermediate filament-based process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN2, C20orf27, and GLT8D1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN2 grouped by Intermediate filament-based process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TLN2 →	-1.171	-0.842	.005	.006	3	4
UPPER_AERODIGESTIVE_TRACT	C20orf27 →	-0.912	-1.130	.004	.002	3	4
UPPER_AERODIGESTIVE_TRACT	GLT8D1 →	-0.856	-1.389	.007	.005	3	4
BREAST	CACTIN →	-0.437	-0.921	.005	.005	3	4
LUNG_NSCLC_LUAD	FAM189B →	-0.759	-0.836	.001	.003	3	4
OVARY	RIC8B →	-0.627	-0.999	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN2 by Intermediate filament-based process activity — BREAST

Explore this box plot interactively →