Intermediate filament-based process

Across TCGA cell cohorts, RNA activity of the Intermediate filament-based process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF2, TLR5, and GZMM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRSF2 grouped by Intermediate filament-based process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SRSF2 →	-0.660	-0.114	<.001	.005	3	5
BONE	TLR5 →	+0.248	+0.234	.005	<.001	3	5
SOFT_TISSUE	GZMM →	+0.224	+0.086	.002	.003	3	5
OESOPHAGUS	PPP1R12A →	+0.383	+0.111	.001	<.001	2	5
LUNG_NSCLC_LUSC	MRPS31P5 →	+0.308	+0.179	.006	.004	3	4
URINARY_TRACT	HTR2A →	+0.180	+0.127	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRSF2 by Intermediate filament-based process activity — LARGE_INTESTINE

Explore this box plot interactively →