Intermediate filament-based process

Across TCGA cell cohorts, RNA activity of the Intermediate filament-based process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKP3, CUEDC2, and PPL, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermediate filament-based process activity versus PKP3 in OVARY (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PKP3 →	+2.979	+0.173	<.001	<.001	3	11
PANCREAS	CUEDC2 →	-0.759	-0.097	<.001	.005	3	10
OVARY	PPL →	+2.585	+0.182	<.001	<.001	3	10
PANCREAS	GPR87 →	+2.880	+0.117	<.001	<.001	3	10
STOMACH	CAST →	+1.453	+0.167	<.001	<.001	3	10
PANCREAS	KLK10 →	+3.438	+0.119	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045103 vs PKP3 — OVARY

Explore this scatter interactively →