Intermediate filament-based process

Across TCGA cell cohorts, RNA activity of the Intermediate filament-based process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLK8, PDXP, and CTSD, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermediate filament-based process activity versus KLK8 in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KLK8 →	+3.261	+0.306	.001	.006	3	8
BLOOD_Lymphoma	PDXP →	-1.343	-0.328	<.001	.001	3	8
LUNG_SCLC	CTSD →	+1.130	+0.365	<.001	.003	3	8
STOMACH	LAMB3 →	+4.505	+0.451	.002	.004	3	8
PANCREAS	CDRT1 →	+1.335	+0.277	.001	.003	3	8
LARGE_INTESTINE	UPK2 →	+2.632	+0.267	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045103 vs KLK8 — BREAST

Explore this scatter interactively →