Negative regulation of viral genome replication

Across TCGA patient cohorts, RNA activity of the Negative regulation of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OIP5, OAS3, and ZBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral genome replication activity versus OIP5 in OV (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	OIP5 →	+0.655	+0.156	.001	.004	3	6
OV	OAS3 →	+1.239	+0.199	.002	.002	2	7
OV	ZBP1 →	+1.062	+0.260	<.001	<.001	3	6
OV	KIF11 →	+0.969	+0.225	<.001	<.001	3	6
OV	CEP55 →	+1.025	+0.185	<.001	.001	3	6
OV	CKAP2L →	+0.783	+0.175	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045071 vs OIP5 — OV

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