Negative regulation of viral genome replication

Across TCGA cell cohorts, RNA activity of the Negative regulation of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD4, IPP, and PFN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral genome replication activity versus PDCD4 in STOMACH (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PDCD4 →	+1.649	+0.256	<.001	.002	3	4
BLOOD_Leukemia	IPP →	+0.960	+0.184	.001	.002	3	4
BLOOD_Lymphoma	PFN2 →	+2.030	+0.199	.002	<.001	3	4
BONE	NIT1 →	+0.646	+0.238	.004	.005	3	4
PANCREAS	ULBP2 →	-1.443	-0.225	<.001	.005	3	4
SOFT_TISSUE	DYNC2LI1 →	+1.176	+0.253	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045071 vs PDCD4 — STOMACH

Explore this scatter interactively →