Regulation of viral genome replication

Across TCGA patient cohorts, RNA activity of the Regulation of viral genome replication pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1, STAT2, and CMPK2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of viral genome replication activity versus STAT1 in LSCC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAT1 →	+0.640	+0.060	<.001	<.001	3	10
GBM	STAT2 →	+0.420	+0.046	<.001	<.001	3	10
UCEC	CMPK2 →	+0.771	+0.090	<.001	<.001	3	10
GBM	MX2 →	+0.990	+0.082	<.001	<.001	3	10
UCEC	OAS2 →	+1.043	+0.102	<.001	<.001	3	10
LSCC	OAS3 →	+0.624	+0.053	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045069 vs STAT1 — LSCC

Explore this scatter interactively →