Regulation of viral genome replication

Across TCGA patient cohorts, RNA activity of the Regulation of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HELLS, CENPL, and POLE2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of viral genome replication activity versus HELLS in LUAD (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HELLS →	+0.696	+0.256	<.001	<.001	3	8
LUAD	CENPL →	+0.532	+0.271	.001	<.001	3	7
LUAD	POLE2 →	+0.810	+0.275	<.001	<.001	3	7
BRCA	KIF18A →	+0.881	+0.257	<.001	<.001	3	7
LSCC	DTL →	+0.926	+0.190	.001	.001	3	7
LUAD	CHEK1 →	+0.800	+0.219	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045069 vs HELLS — LUAD

Explore this scatter interactively →