Regulation of viral genome replication

Across TCGA cell cohorts, RNA activity of the Regulation of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC30A5, EXOSC8, and LARGE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC30A5 grouped by Regulation of viral genome replication-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC30A5 →	-0.619	-0.194	.005	.002	3	5
LUNG_NSCLC_LUAD	EXOSC8 →	+0.859	+0.147	<.001	.004	3	4
LUNG_NSCLC_LUAD	LARGE1 →	-1.056	-0.132	.002	.007	3	4
LUNG_NSCLC_LUAD	BUD13 →	+0.622	+0.155	.005	.002	3	4
BONE	NOL3 →	-1.730	-0.276	.006	.007	3	4
LUNG_NSCLC_LUSC	NLRC5 →	+1.359	+0.124	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC30A5 by Regulation of viral genome replication activity — SOFT_TISSUE

Explore this box plot interactively →