Regulation of viral genome replication

Across TCGA cell cohorts, RNA activity of the Regulation of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENY2, CISD3, and TATDN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of viral genome replication activity versus ENY2 in LIVER (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ENY2 →	+0.604	+0.183	.003	.002	3	5
BLOOD_Myeloma	CISD3 →	+0.984	+0.216	.006	.003	3	5
LUNG_NSCLC_LUAD	TATDN2 →	+0.568	+0.169	<.001	<.001	3	5
LUNG_NSCLC_LUAD	COPRS →	+0.741	+0.129	<.001	<.001	3	5
OVARY	GTPBP3 →	+0.870	+0.178	.004	.001	2	6
OVARY	USP21 →	+0.729	+0.187	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045069 vs ENY2 — LIVER

Explore this scatter interactively →