Regulatory T cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulatory T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGLEC10, CLEC4E, and NCBP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulatory T cell differentiation activity versus SIGLEC10 in LUAD (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SIGLEC10 →	+0.475	+0.407	.002	.004	3	4
COAD	CLEC4E →	+0.625	+0.553	.002	.008	2	5
UCEC	NCBP2 →	+0.373	+0.818	.002	<.001	3	4
LSCC	SLC6A1 →	-0.234	-0.206	<.001	<.001	3	4
LSCC	MFAP3L →	-0.835	-0.274	<.001	<.001	3	4
COAD	JAK3 →	+0.510	+0.752	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045066 vs SIGLEC10 — LUAD

Explore this scatter interactively →