Regulatory T cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulatory T cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT8, KAT5, and KCNK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUDT8 grouped by Regulatory T cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUDT8 →	-0.204	-0.972	.008	.001	3	6
SOFT_TISSUE	KAT5 →	-0.359	-0.899	<.001	.006	3	5
LUNG_NSCLC_LUSC	KCNK3 →	-0.211	-1.312	<.001	.001	3	5
OVARY	AGER →	-0.118	-0.912	.003	.004	3	5
LUNG_NSCLC_LUAD	HLA-DRB1 →	-0.209	-1.390	<.001	<.001	2	6
BLOOD_Lymphoma	PCSK5 →	-0.184	-0.272	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUDT8 by Regulatory T cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →