Regulatory T cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulatory T cell differentiation pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are KU-60019, CCT245232, and RAF_9304, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KU-60019 grouped by Regulatory T cell differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KU-60019 →	-0.525	-1.437	.034	.010	1	1
BLOOD_Leukemia	CCT245232 →	-0.669	-1.437	.035	.010	1	1
BLOOD_Leukemia	RAF_9304 →	-0.965	-1.437	.026	.010	1	1
BLOOD_Leukemia	DMOG →	+0.484	+1.437	.015	.010	1	1
BLOOD_Leukemia	TAF1_5496 →	+0.474	+1.437	.033	.010	1	1
BLOOD_Leukemia	GSK650394 →	+0.570	+1.437	.012	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KU-60019 by Regulatory T cell differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →