T-helper 1 cell differentiation

Across TCGA patient cohorts, RNA activity of the T-helper 1 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAK3, ARRDC5, and CD2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 1 cell differentiation activity versus JAK3 in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JAK3 →	+1.103	+0.617	<.001	<.001	3	9
LSCC	ARRDC5 →	+0.483	+0.506	<.001	<.001	3	9
GBM	CD2 →	+1.360	+0.548	<.001	<.001	3	8
GBM	LILRB2 →	+0.762	+0.440	<.001	<.001	3	8
HNSC	NCF1 →	+0.970	+0.471	<.001	<.001	3	8
LSCC	FCRL3 →	+0.814	+0.856	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045063 vs JAK3 — GBM

Explore this scatter interactively →